Preparation and anti-cancer activity of polymer-encapsulated curcumin nanoparticles

    Phuong Thu Ha 1
    Mai Huong Le 2
    Thi My Nhung Hoang 3
    Thi Thu Huong Le 4
    Tuan Quang Duong 5
    Thi Hong Ha Tran 2
    Dai Lam Tran 1
    Xuan Phuc Nguyen 1

    Advances in Natural Sciences: Nanoscience and Nanotechnology - Vol. 3, No. 2 (2012)

    1. Institute of Materials Science (IMS), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam
    2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi, Vietnam
    3. Hanoi University of Science, Vietnam National University, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam
    4. Hanoi University of Agriculture, Trau Quy, Gia Lam, Hanoi, Vietnam
    5. Department of Chemistry, Hue University, 34 Le Loi, Hue City, Vietnam

    Tiếng Anh

    Tóm tắt

    Curcumin (Cur) is a yellow compound isolated from rhizome of the herb curcuma longa. Curcumin possesses antioxidant, anti-inflammatory, anti-carcinogenic and antimicrobial properties, and suppresses proliferation of many tumor cells. However, the clinical application of curcumin in cancer treatment is considerably limited due to its serious poor delivery characteristics. In order to increase the hydrophilicity and drug delivery capability, we encapsulated curcumin into copolymer PLA-TPGS, 1,3-beta-glucan (Glu), O-carboxymethyl chitosan (OCMCs) and folate-conjugated OCMCs (OCMCs-Fol). These polymer-encapsulated curcumin nanoparticles (Cur-PLA-TPGS, Cur-Glu, Cur-OCMCs and Cur-OCMCs-Fol) were characterized by infrared (IR), fluorescence (FL), photoluminescence (PL) spectra, field emission scanning electron microscopy (FE-SEM), and found to be spherical particles with an average size of 50–100 nm, being suitable for drug delivery applications. They were much more soluble in water than not only free curcumin but also other biodegradable polymer-encapsulated curcumin nanoparticles. The anti-tumor promoting assay was carried out, showing the positive effects of Cur-Glu and Cur-PLA-TPGS on tumor promotion of Hep-G2 cell line in vitro. Confocal microscopy revealed that the nano-sized curcumin encapsulated by polymers OCMCs and OCMCs-Fol significantly enhanced the cellular uptake (cancer cell HT29 and HeLa).

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