Iron oxide-based conjugates for cancer theragnostics

Tóm tắt

In this paper we first summarize our recent research on fabrication and structure characterization of conjugates of Fe3O4 nanoparticles (MNPs) encapsulated by several organic materials such as oleic acid (OL), starch (ST), dextran (D), chitosan (CS), O-carboxymethyl chitosan (OCMCS) and the copolymer of poly(styrene-co-acrylic acid (St-co-AA)). The ferrofluids stability and toxicity were also considered. The magnetic inductive heating (MIH) curves were measured using a set up with an alternating (ac) magnetic field of strength of 40–100 Oe and frequency of 180–240 kHz. We then present new results dealing with attempting to apply the MNP/copolymer ferrofluid for treatment of Sarcoma 180 tumor. In vitro as well as ex vivo MIH experiments were carried out as preparation steps in order to estimate the proper conditions for the in vivo MIH experiment. As for the latter, we have successfully carried out the treatment of solid tumor of size around 6 × 6 mm inoculated on Swiss mice with use of a dose of 0.3–0.4 mg ml−1 ferrofluid injected subcutaneously into the tumor and field-irradiated for 30 min. Two groups of treated mice recovered in three weeks from MIH treatment three times during the first week. We finally show that curcumin loaded MNP-based conjugates showed themselves to be a potential agent for application as a bimodal contrast enhancer of magnetic resonance imaging (MRI) and fluorescence imaging. Additionally, in vitro and ex vivo studies by these two techniques evidenced that macrophage is capable of uptake and tends to carry the MNPs into a tumor.

Tài liệu tham khảo

[1] Ferrieri M 2005 Nature Rev. Cancer 5 161 Brigger I, Dubernet C and Couvreur P 2002 Adv. Drug Deliv. Rev. 54 63

[2] Shubayev V, Pisanic T R and Jin S H 2009 Adv. Drug Rev. 61 467

[3] Takae S, Akiyama Y, Otsuka H, Nakamura T, Nagasaki Y and Kataoka K 2005 Biomacromol. 6 818

[4] Panchurst Q A, Connolly J, Jones S K and Dobson J 2003 J. Phys. D: Appl. Phys. 36 R167 Pankhurst Q A, Thanh N K T, Jones S K and Dobson J 2009 J. Phys. D: Appl. Phys. 42 4001

[5] Moenet S, Vasseur S, Grasset F and Duguet E 2004 J. Mater. Chem. 14 2161

[6] Gupta A K and Gupta M 2005 Biomaterials 26 3995

[7] Lu A H, Salabas E L and Schulth F 2007 Angew Chem., Int. Ed. Engl. 46 1222

[8] Lee J-H, Jiang J-T, Choi J-S, Moon S H, Noh S-H, Kim J-W, Kim J-G, Park K I and Cheon J 2011 Nature Nanotechnol. 6 418

[9] Park J K, Jung J, Subramania P, Shah B P, Kim C, Lee J K, Cho J H, Lee C and Lee K-B 2011 Small 7 1647

[10] Pantic I 2010 Rev. Adv. Mater. Sci. 26 67

[11] Lacroix L-M, Ho D and Sun S 2010 Curr. Top. Med. Chem. 10 1184

[12] Wang Y-X J, Hussain S M and Krestin G P 2001 Eur. Radiol. 11 2319

[13] Prashant C, Dipak M, Yang C-T, Chuang K-H, Jun D and Feng S-S 2010 Biomaterials 31 5588

[14] Yanase M, Shinkai M, Honda H, Wakabayashi T, Yoshida J and Kobayashi T 1998 Japan. J. Cancer Res. 89 463 Ito A, Shinkai M, Honda H and Kobayashi T 2001 Cancer Gene Ther. 8 649

[15] Brusentsov N A, Nikitin L V, Brusentsova T N, Kuznetsov A A, Bayburskiy F S, Shumakov L I and Jurchenko N Y 2002 J. Magn. Magn. Mater. 252 378

[16] Gneveckow U, Jordan A, Scholz R, Brub V, Waldofner N, Ricke J, Feussner A, Hildebrant B, Rau B and Wust P 2004 Med. Phys. 31 1444

[17] Hilger I, Hergt R and Kaiser W A 2005 IEE Proc.—Nanotechnol. 152 33

[18] Pham H L, Do H M, Tran D L, Le V H, Nguyen X P, Nguyen A T, Nguyen T N and Vu A T 2011 Int. J. Nanotechnol. 8 399

[19] Pham H L, Nguyen C T, Nguyen A T, Pham V T, Tran C Y, Nguyen T Q, Hoang T M N, Phi T X, Nguyen X P and Le V H 2009 J. Phys.: Conf. Series 187 012008

[20] Ha P T, Tran T M N, Pham H D, Nguyen Q H and Nguyen X P 2010 Adv. Nature. Sci.: Nanosci Nanotechnol. 1 015012

[21] Tran D L et al 2010 Colloid. Surf. A 371 104 [22] Luong T T et al 2011 Colloid. Surf. A 384 23

[23] Mai T T, Ha P T, Pham H N, Le T T H, Pham H L, Phan T B H, Tran D L and Nguyen X P 2012 Adv. Nature Sci.: Nanosci. Nanotechnol. 3 015006

[24] Ha P T et al 2011 Chem. Lett. 40 1264

[25] Muthana M, Scott S D, Farrow M, Morrow F, Murdoch C, Grubb S, Brown N, Dobson J and Lewis C E 2008 Gene Ther. 15 902

Các bài trích dẫn đến

1. Ganeshlenin Kandasamy, Dipak Maity. Recent advances in superparamagnetic iron oxide nanoparticles (SPIONs) for in vitro and in vivo cancer nanotheranostics in International Journal of Pharmaceutics (Vol. 496, No. 2, 2015)
2. RR Wildeboer, P Southern, QA Pankhurst. On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials in Journal of Physics D: Applied Physics (Vol. 47, No. 49, 2014)
3. Nguyen Viet Long, Yong Yang, Toshiharu Teranishi, Cao Minh Thi, Yanqin Cao, Masayuki Nogami. Biomedical applications of advanced multifunctional magnetic nanoparticles in Journal of nanoscience and nanotechnology (Vol. 15, No. 12, 2015)
4. Maria Filippousi, Mavroeidis Angelakeris, Maria Katsikini, Eleni Paloura, Ilias Efthimiopoulos, Yuejian Wang, Demetris Zamboulis, Gustaaf Van Tendeloo. Surfactant effects on the structural and magnetic properties of iron oxide nanoparticles in The Journal of Physical Chemistry C (Vol. 118, No. 29, 2014)
5. Anh-Tuan Le, Thi Tam Le, Huy Hoang Tran, Duc Anh Dang, Quang Huy Tran, Dinh Lam Vu. Powerful colloidal silver nanoparticles for the prevention of gastrointestinal bacterial infections in Advances in Natural Sciences: Nanoscience and Nanotechnology (Vol. 3, No. 4, 2012)
6. Hong Nam Pham, Thi Ha Giang Pham, Dac Tu Nguyen, Quoc Thong Phan, Thi Thu Huong Le, Phuong Thu Ha, Hung Manh Do, Thi My Nhung Hoang, Xuan Phuc Nguyen. Magnetic inductive heating of organs of mouse models treated by copolymer coated Fe3O4 nanoparticles in Advances in Natural Sciences: Nanoscience and Nanotechnology (Vol. 8, No. 2, 2017)
7. Seonghee Kang, Jeonghwan Kim, Dokyung Kim, Bosun Kang. A Research on Superparamagnetic Iron Oxide NanoparticlesToxicity to U373MG Cell and its Effect on the Radiation Survival Curve in Journal of the Korean Society of Radiology (Vol. 6, No. 6, 2012)
8. Thi Thu Huong Le, Thuc Quang Bui, Thi Minh Thi Ha, Mai Huong Le, Hong Nam Pham, Phuong Thu Ha. Optimizing the alginate coating layer of doxorubicin-loaded iron oxide nanoparticles for cancer hyperthermia and chemotherapy in Journal of materials science (Vol. 53, No. 19, 2018)
9. NH Sulaiman, MJ Ghazali, BY Majlis, J Yunas, M Razali. Influence of calcination temperatures on structure and magnetic properties of calcium ferrite nanoparticles synthesized via sol-gel method in Jurnal Tribologi (Vol. 12, 2017)
10. Weibo Cai, Feng Chen. Hybrid Nanomaterials: An Introduction in Hybrid Nanomaterials (2017)
11. Jin Chen, Ling Chen, Fengwei Xie, Xiaoxi Li. Starch-Based DDSs with Stimulus Responsiveness in Drug Delivery Applications of Starch Biopolymer Derivatives (2019)
12. Guobing Liu, Hongcheng Shi, Dengfeng Cheng. Multifunctional Nanoparticles: Design and Application in Diagnosis of Cardiovascular Diseases in Hybrid Nanomaterials (2017)
13. Phuong Thu Ha, Thi Thu Huong Le, Thuc Quang Bui, Hong Nam Pham, Anh Son Ho, Linh Toan Nguyen. Doxorubicin release by magnetic inductive heating and in vivo hyperthermia-chemotherapy combined cancer treatment of multifunctional magnetic nanoparticles in New Journal of Chemistry (2019)
14. Jin Chen, Ling Chen, Fengwei Xie, Xiaoxi Li. Toxicology of Starch-Based DDSs in Drug Delivery Applications of Starch Biopolymer Derivatives (2019)
15. 강성희, 김정환, 김도경, 강보선. 산화철 나노입자의 U373mg 세포 독성평가 및 방사선 세포생존 곡선에 미치는 영향에 대한 연구 in Journal of the Korean Society of Radiology (Vol. 6, No. 6, 2012)