Biomedical and environmental applications of magnetic nanoparticles

Tóm tắt

This paper presents an overview of syntheses and applications of magnetic nanoparticles (MNPs) at the Institute of Materials Science, Vietnam Academy of Science and Technology. Three families of oxide MNPs, magnetite, manganite and spinel ferrite materials, were prepared in various ways: coprecipitation, sol–gel and high energy mechanical milling. Basic properties of MNPs were characterized by Vibrating Sample Magnetometer (VSM) and Physical Properties Measurement Systems (PPMS). As for biomedical application, the aim was to design a novel multifunctional, nanosized magnetofluorescent water-dispersible Fe3O4-curcumin conjugate, and its ability to label, target and treat tumor cells was described. The conjugate possesses a magnetic nano Fe3O4 core, chitosan (CS) or Oleic acid (OL) as an outer shell and entrapped curcumin (Cur), serving the dual function of naturally autofluorescent dye as well as antitumor model drug. Fe3O4-Cur conjugate exhibited a high loading cellular uptake with the help of a macrophage, which was clearly visualized dually by Fluorescence Microscope and Laser Scanning Confocal Microscope (LSCM), as well as by magnetization measurement (PPMS). A preliminary magnetic resonance imaging (MRI) study also showed a clear contrast enhancement by using the conjugate. As for the environmental aspect, the use of magnetite MNPs for the removal of heavy toxic metals, such as Arsenic (As) and Lead (Pb), from contaminated water was studied.

Từ khoá

Keywords: magnetic nanoparticles, magnetic heating, hyperthermia, heavy ion removal

Tài liệu tham khảo

[1] An-Hui A L, Salabas E L and Schuth F 2007 Angew. Chem. Int. Ed. Engl. 46 1222

[2] Andra W, Hafeli U, Hergt R and Misri R 2007 Application of magnetic particles in medicine and biology Handbook of Magnetism and Advanced Magnetic Materials vol 4 ed H Kronmuller and S Parkin (Chichester: Wiley)

[3] Pankhurst Q A, Thanh N T K, Jones S K and Dobson J 2009 J. Phys. D: Appl. Phys. 42 224001

[4] Jordan A, Scholz R, Wust P, Fahling H and Felix R 1999 J. Magn. Magn. Mater. 201 413

[5] Kikukawa, Takemori N, Nagano M, Sugasawa Y and Kobayashi M 2004 J. Magn. Magn. Mater. 284 206

[6] You C C, Chompoosor A and Rotello V M 2007 Nanotoday 2–3 34

[7] Lu A H, Salabas E L and Schuth F 2007 Angew. Chem. Int. Ed. Engl. 46 1222

[8] Moroz P, Jones S K and Gray B N 2002 Int. J. Hyperth. 18 267

[9] Hoang T V, Lam T D and Thinh N N 2010 Mater. Sci. Eng. C 30 304

[10] Ngo T H, Tran D L, Tran V H, Do H M, Tran D T and Nguyen X P 2010 Adv. Nat. Sci.: Nanosci. Nanotechnol. 1 035001

[11] Tran D L et al 2010 Colloids Surf. A 371 104

Các bài trích dẫn đến

1. RR Wildeboer, P Southern, QA Pankhurst. On the reliable measurement of specific absorption rates and intrinsic loss parameters in magnetic hyperthermia materials in Journal of Physics D: Applied Physics (Vol. 47, No. 49, 2014)
2. N Griffete, H Li, A Lamouri, C Redeuilh, K Chen, C-Z Dong, S Nowak, S Ammar, C Mangeney. Magnetic nanocrystals coated by molecularly imprinted polymers for the recognition of bisphenol A in Journal of Materials Chemistry (Vol. 22, No. 5, 2012)
3. Isa Karimzadeh, Hamid Rezagholipour Dizaji, Mustafa Aghazadeh. Preparation, characterization and PEGylation of superparamagnetic Fe3O4 nanoparticles from ethanol medium via cathodic electrochemical deposition (CED) method in Materials Research Express (Vol. 3, No. 9, 2016)
5. Obadia K Bishoge, Lingling Zhang, Shaldon L Suntu, Hui Jin, Abraham A Zewde, Zhongwei Qi. Remediation of water and wastewater by using engineered nanomaterials: a review in Journal of Environmental Science and Health, Part A (Vol. 53, No. 6, 2018)
6. Samta Chauhan, Amit Kumar Singh, Saurabh Kumar Srivastava, Ramesh Chandra. Study of magnetic behavior in hexagonal-YMn1− xFexO3 (x= 0 and 0.2) nanoparticles using remanent magnetization curves in Journal of Magnetism and Magnetic Materials (Vol. 414, 2016)
7. Monika Jain, Mithilesh Yadav, Tomas Kohout, Manu Lahtinen, Vinod Kumar Garg, Mika Sillanpää. Development of iron oxide/activated carbon nanoparticle composite for the removal of Cr (VI), Cu (II) and Cd (II) ions from aqueous solution in Water resources and industry (Vol. 20, 2018)
8. Naga Veera Srikanth Vallabani, Sanjay Singh, Ajay Karakoti. Magnetic Nanoparticles: Current Trends and Future Aspects in Diagnostics and Nanomedicine in Current drug metabolism (2019)
10. Monika Jain, Mithilesh Yadav, Tomas Kohout, Manu Lahtinen, Vinod Kumar Garg, Mika Sillanpää. Water Resources and Industry
11. Alexandrina Nan, Iolanda-Veronica Ganea, Rodica Turcu. Physicochemical Properties of a New Magnetic Nanostructure Based on Poly (Benzofurane-co-Arylacetic Acid) in Analytical Letters (Vol. 52, No. 1, 2019)
12. Mugdha Rao, Anal K Jha, Kamal Prasad. Nanomaterials: An Upcoming Fortune to Waste Recycling in Exploring the Realms of Nature for Nanosynthesis (2018)
13. Varalakshmi Raguraman, K Suthindhiran. Comparative ecotoxicity assessment of magnetosomes and magnetite nanoparticles in International journal of environmental health research (2019)