Apoptosis induced by paclitaxel-loaded copolymer PLA–TPGS in Hep-G2 cells
1. Institute of Materials Science, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
2. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
3. Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, 18 Hoang Quoc Viet, Cau Giay, Hanoi, Vietnam
Tiếng Anh
Tóm tắt
Paclitaxel is an important anticancer drug in clinical use for treatment of a variety of cancers.
The clinical application of paclitaxel in cancer treatment is considerably limited due to its
serious poor delivery characteristics. In this study paclitaxel-loaded copolymer
poly(lactide)–d-α-tocopheryl polyethylene glycol 1000 succinate (PLA–TPGS) nanoparticles
were prepared by a modified solvent extraction/evaporation technique. The characteristics of
the nanoparticles, such as surface morphology, size distribution, zeta potential, solubility and
apoptosis were investigated in vitro. The obtained spherical nanoparticles were negatively
charged with a zeta potential of about −18 mV with the size around 44 nm and a narrow size
distribution. The ability of paclitaxel-loaded PLA–TPGS nanoparticles to induce apoptosis in
human hepatocellular carcinoma cell line (Hep-G2) indicates the possibility of developing
paclitaxel nanoparticles as a potential universal cancer chemotherapeutic agent.
Tài liệu tham khảo
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[2] Gershlick A et al 2004 Circulation 109 487
[3] Peer D, Karp J M, Hong S, Farokhzad O C, Margalit R and Langer R 2007 Nat. Nanotechnol. 2 751
[4] Blanco E, Hsiao A, Mann A P, Landry M G, Meric-Bernstam F and Ferrari M 2011 Cancer Sci. 102 1247
[5] Yokoyama M, Kwon G S, Okano T, Sakurai Y, Seto T K and Kataoka K 1992 Bioconjug. Chem. 3 295
[6] Kazunori K, Glenn S K, Masayuki Y, Teruo O and Yasuhisa S 1993 J. Control. Release 24 119
[7] Kwon G S and Okano T 1996 Adv. Drug Deliv. Rev. 21 107
[8] Jones M and Leroux J 1999 Eur. J. Pharm. Biopharm. 48 101
[9] Torchilin V P 2004 Cell. Mol. Life Sci. 61 2549
[10] Wiradharma N, Zhang Y, Venkataraman S, Hedrick J L and Yang Y Y 2009 Nano Today 4 302
[11] Kim J Y, Kim S, Pinal R and Park K 2011 J. Control. Release 152 13
[12] Zhang Z, Yang X and Feng S S 2011 Nanomedicine 6 583
[13] Ha P T et al 2011 Chem. Lett. 40 1264
[14] Zhao Y, Li J, Yu H, Wang G and Liu W 2012 Int. J. Pharm. 430 282
[15] Le M H, Ha P T, Nguyen T B T, Tran T H H, Ha T M T, Mai T T, Tran T N H, Do H N, Nguyen X P and Duong T Q 2011 Chem. Lett. 40 846
[16] Rancan F, Papakostas D, Hadam S, Hackbarth S, Delair T, Primard C, Verrier B, Sterry W, Blume-Peytavi U and Vogt A 2009 Pharm. Res. 26 2027
[17] Lee S H, Zhang Z and Feng S S 2007 Biomaterials 28 2041
[18] Oh J K 2011 Soft Matter 7 5096
[19] Mu L and Feng S S 2003 J. Control. Release 86 33
[20] Aishwarya S, Mahalakshmi S and Sehgal P K 2008 J. Microencapsul. 25 298
[21] Collnot E M, Baldes C, Schaefer U F, Edgar K J, Wempe M F and Lehr C M 2010 Mol. Pharm. 7 642
[22] Muthu M S, Kulkarni S A, Xiong J and Feng S S 2011 Int. J. Pharm. 421 332
[23] Zhang Z, Tan S and Feng S S 2012 Biomaterials 33 4889
[24] Ha P T, Tran T M N, Pham H D, Nguyen Q H and Nguyen X P 2010 Adv. Nat. Sci.: Nanosci. Nanotechnol. 1 015012
[25] Mu L and Feng S S 2003 Pharm. Res. 20 1864
[26] Zhang Z and Feng S S 2006 Int. J. Pharm. 324 191
[27] Liang C, Yang Y, Ling Y, Huang Y, Li T and Li X 2011 Bioorg. Med. Chem. 19 4057
[28] Shi M, Cai Q, Yao L, Mao Y, Ming Y and Ouyang G 2006 Cell Biol. Int. 30 221
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