The synthesis of poly(lactide)-vitamin E TPGS (PLA-TPGS) copolymer and its utilization to formulate a curcumin nanocarrier

Tóm tắt

Curcumin is a natural substance that exhibits the ability to inhibit and/or treat carcinogenesis in a variety of cell lines, but because of its poor solubility in water the treatment efficacy is limited. In this paper we report on the fabrication of self-assembled micelle nanoparticles loaded with a curcumin drug by use of a biocompatible copolymer of PLA-TPGS (d-a-tocopheryl polyethylene glycol 1000 succinate—vitamin E TPGS) conjugate. The polylactide (PLA)-TPGS copolymer synthesized by ring-opening polymerization was characterized by Fourier transform infrared spectroscopy (FTIR) and 1H nuclear magnetic resonance (1H NMR) techniques. The surface morphology of PLA-TPGS and curcumin loaded PLA-TPGS was determined by field emission scanning electron microscopy (FE-SEM). The absorption and fluorescence examinations indicated that due to micellar capsulation the intensity of both types of spectra increased by about 4 times in comparison with those of the free curcumin sample.

Tài liệu tham khảo

Aggarwal B B and Shishodia S 2006 Biochem. Pharmacol. 71 1379
Choi H, Chun Y S, Kim S W, Kim M S and Park J W 2006 Mol. Pharmacol. 70 1664
Srivastava K C, Bordia A and Verma S K 1995 Prostaglandins Leukot. Essent. Fatty Acids 52 223
Aggarwal B B, Kumar A and Bharti A C 2003 Anticancer Res. 23 363
Balasubramanyam K, Varier R A, Altaf M, Swaminathan V, Siddappa N B, Ranga U and Kundu T K 2004 J. Biol. Chem. 279 51163
Li L, Ahmed B, Mehta K. and Kurzrock R 2007 Mol. Cancer Ther. 6 1276
Clifford N W, Swamninathan Iyer K and Raston C L 2008 J. Mater. Chem. 18 162
Bisht S, Feldmann G, Soni S, Ravi R, Karikar C, Amornath M and Aniirban M 2007 J. Nanobiotechnol. 5 3
Sahu A, Bora U, Kasoju N and Goswami P 2008 Acta Biomater. 4 1752
Matsumura , Hamaguchi Y T, Ura T, Muro K, Yamada Y, Shimada Y, Shirao K, Okusaka T, Ueno H, Ikeda M and Watanabe N 2004 Br. J. Cancer 91 1775
Mu L and Seow P H 2006 Colloids Surf. B 47 90
Zhang Z P and Feng S S 2006 Biomaterials 27 262
Pan J and Feng S S 2008 Biomaterials 29 2663
Iwunze M O 2003 Tenside Surf. Det. 40 96
Wang F, Wu X, Wang F, Liu S F, Jia Z and Yang J H 2006 J. Fluoresc. 16 53
Kunwar A, Barik A, Mishra B, Rathinasamy K, Pandey R and Priyadarsini K I 2008 Biochim. Biophys. Acta 1780 673

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