Magnetic inductive heating of organs of mouse models treated by copolymer coated Fe

Tóm tắt

Biodistribution studies provide basic information to design and perform various applications of superparamagnetic iron oxide magnetic nanoparticles (SPIOs) in biomedicine such as drug delivery, MRI as well as hyperthermia. Recently, several quantitative measurements as well as new imaging methods have been used to characterize the SPIOs distribution in organs and in tissues of animal model. In this report we used the fabricated iron oxide nanoparticles coated with two block copolymers of polystyrene-co-polyacrylic acid (St-co-PAA) and polylactic acid-co-polyethylene glycol (PLA-PEG). The biodistributions were investigated ex-vivo for several organs of both healthy and Sarcoma transplanted Swiss mice. The SPIOs concentrations were verified mainly by magnetic inductive heating (MIH) measurement with a combination with atomic absorption spectroscopy (AAS). The results indicated the density detected highest in liver and lowest in kidney. The SPIOs concentration increased significantly up to 24 h after the injection. The observations by our two methods not only are in agreement with each other but also consistent with the tendency reported by other techniques. Discussion will also concern injection strategy for various aspects of hyperthermia applications.

Tài liệu tham khảo

Lu A H, Salabas E L and Schulth F 2007 Angew Chem., Int. Ed. Engl. 46 1222
Pankhurst Q A, Connolly J, Jones S K and Dobson J 2003 J. Phys. D: Appl. Phys. 36 167
Thanh N T K (ed) 2014 Magnetic Nanoparticles: from Fabrication to Clinical Application (Boca Raton, FL: CRC Press)
Arruebo M, Fernandez-Pacheco R, Ibarra M and Santamaria J 2007 Nano Today 2 22
Etheridge M L, Xu Y, Rott L, Choi J, Glasmacher B, John C and Bischof R F 2014 Technology 2 229
Wang J, Zhao G, Zhang Z, Xu X and He X 2016 Acta Biomater. 33 264
Rosensweig R E 2002 J. Magn. Magn. Mater. 252 370
Moroz P, Jones S K and Gray B N 2002 Int. J. Hyperth. 18 267
Banobre-Lopez M, Teijeiro R and Rivas J 2002 Rep. Pract. Oncol. Radiother. 18 397
Brazel C S 2009 Pharm. Res. 26 644
Purushotham S and Ramanujan R V 2010 Acta Biomater. 6 502
Zhang J and Misra R D K 2007 Acta Biomater. 3 838
Mai T T T, Le T H P, Pham H N, Do H M and Nguyen X P 2014 Adv. Nat. Sci.: Nanosci. Nanotechnol. 5 045007
Nayashi K, Ono K, Suzuki H, Sawada M, Moriya M, Sakamoto W and Yogo T 2010 ACS Appl. Mater. Interface 2 1903
Gordon R T, Hines J R and Gordon D 1979 Med. Hypothesis 5 83
Gneveckow U, Jordan A, Scholz R, Brub V, Waldofner N, Ricke J, Feussner A, Hildebrant B, Rau B and Wust P 2004 Med. Phys. 31 1444
da Silva A C, Oliveira T R, Mamani J B, Malheiros S M F, Pavon L F, Sibov T T, Junior E A and Gamarra L F 2010 Einstein 8 361
Deatsch A E and Evans B A 2014 J. Magn. Magn. Mater. 354 163
Nikitin M, Yuriev M, Brusensov N, Votosko P and Nikitin P 2010 Non-invasive in-vivo mapping and long-term monitoring of magnetic nanoparticles in different organs of animals AIP Conf. Proc. 1311 452
Zhuang J, Fan K, Gao L, Lu D, Feng J, Yang D, Gu N, Zhang Y, Liang M and Yan X 2012 Mol. Pharm. 9 1983
Mejfas R et al 2010 Nanomedicine 5 397
Gutiérrez L, Mejías R, Barber D F, Veintemillas-Verdaguer S, Serna C J, Lázaro F J and Morales M P 2011 J. Phys. D: Appl. Phys. 44 255002
López A, Gutiérrez L and Lázaro F J 2007 Phys. Med. Biol. 52 5043
Lazaro F J, Abadia A R, Romeo M S, Gutierrez L, Lazaro J and Morales M P 2005 Biochim. Biophys. Acta 174 434
Lazaro F J, Gutierrez L, Abadia A R, Romero M S, Lopez A and Murioz J 2007 J. Magn. Magn. Mater. 311 460
Gutiérrez L, Lázaro F J, Abadía A R, Romero M S, Quintana C, Puerto Morales M, Patiño C and Arranz R 2006 J. Inorg. Biochem. 100 1790
Srinivasan M, Subramanian S and Upadhyay L 2012 Asian J. Chem. 24 1689
Wortmann A C, Froehlich P E, Pinto R B, Magalhaes R B, Alvares-da-Silva M R, Feireira J J and Silveira T R 2007 Spectroscopy 21 161
Papanastasiou D A, Vayenas D V, Vassilopoulos A and Rapanti M 2000 Pathol. Res. Pract. 196 47
Luong T T et al 2011 Colloids Surf. A 384 23
Nguyen X P et al 2012 Adv. Nat. Sci.: Nanosci. Nanotechnol. 3 033001
Thong P Q, Thu H P, Huong L T T, Nguyen L H and Phuc N X 2016 Structure and properties of Fe3O4 nanoparticles coated by PLA-PEG copolymer with and without loading of curcumin J. Sci. Technol. (VAST) 54 268
Wagner S, Schnorr J, Pilgrimm H, Hamm B and Taupitz M 2002 Invest. Radiol. 37 167