Curcumin as fluorescent probe for directly monitoring in vitro uptake of curcumin combined paclitaxel loaded PLA-TPGS nanoparticles

    Hoai Nam Nguyen 1
    Phuong Thu Ha 1
    Anh Sao Nguyen 2
    Dac Tu Nguyen 2
    Hai Doan Do 1
    Quy Nguyen Thi 2
    My Nhung Hoang Thi 2

    Advances in Natural Sciences: Nanoscience and Nanotechnology - Vol. 7, No. 2 (2016)

    1. 1 Institute of Materials Science, Vietnam Academy of Science and Technology
    2. Hanoi University of science

    Tiếng Anh

    Tóm tắt

    Theranostics, which is the combination of both therapeutic and diagnostic capacities in one dose, is a promising tool for both clinical application and research. Although there are many chromophores available for optical imaging, their applications are limited due to the photobleaching property or intrinsic toxicity. Curcumin, a natural compound extracted from the rhizome of curcuma longa, is well known thanks to its bio-pharmaceutical activities and strong fluorescence as biocompatible probe for bio-imaging. In this study, we aimed to fabricate a system with dual functions: diagnostic and therapeutic, based on poly(lactide)-tocopheryl polyethylene glycol succinate (PLA-TPGS) micelles co-loaded curcumin (Cur) and paclitaxel (PTX). Two kinds of curcumin nanoparticle (NP) were fabricated and characterized by Fourier transform infrared spectroscopy, field emission scanning electron microscopy and dynamic light scattering methods. The cellular uptake and fluorescent activities of curcumin in these systems were also tested by bioassay studies, and were compared with paclitaxe-oregon. The results showed that (Cur + PTX)-PLA-TPGS NPs is a potential system for cancer theranostics.

    Từ khoá

    Theranostics, curcumin, paclitaxel, drug delivery nanosystem, fluorescent probe

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